Biomedical Research

Objective: To investigate the efficacy of tanreqing injection combined with Ribavirin for hand-footmouth disease complicated with pneumonia and its influence on serum inflammatory factors.

Methods: 72 children with hand-foot-mouth disease complicated with bronchopneumonia were recruited from January 2016 to June 2017 in our hospital, and randomly divided into observation group (n=36) and control group (n=36). The control group was treated with ribavirin injection, and the observation group was treated with tanreqing injection on the basis of the control group. The time of symptoms and signs improvement, and the changes of Interleukin-2 (IL-2), Interleukin-6 (IL-6), Interleukin-10 (IL-10), C-Reactive Protein (CRP) and Tumor Necrosis Factor-α (TNF-α) were compared between the two groups.

Results: The time of pyretolysis, rash subsided, oral mucosal congestion, disappearance of cough and rales in the observation group were significantly less than those in the control group (t=9.667, 4.577, 7.526, 3.651, 5.677, all P<0.05); after treatment, the levels of IL-2, IL-6 and IL-10 in the two groups were significantly decreased (t=6.773, 6.164, 7.581, 2.781, 2.434, 3.023, all P>0.05), and the above indexes in the observation group were significantly lower than those in the control group (t=5.415, 4.616, 4.365, all P<0.05); after treatment, the levels of CRP and TNF-α in the two groups were significantly decreased (t=13.486, 40.914, 14.136, 32.922, all P<0.05), and the above indexes in the observation group were significantly lower than those in the control group (t=16.619, 23.077, all P<0.05).

Conclusion: Tanreqing injection combined with ribavirin can effectively promote the rehabilitation of hand-foot-mouth disease complicated with pneumonia, and reduce the levels of inflammatory factors in serum.

Author(s): Hui-ying Yu, Xin-qiang Lu, Hai-ying Yu
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