Biomedical Research

Respiratory function measurement in dog has been limited by the side effects of anesthetic drugs. In this context, a method for respiratory function measurement in conscious dog has been developed. A headout body plethysmography has been utilized for measuring the tidal volume; a facemask has been utilized for measuring the airway flow. A wireless-telemetry implant has been placed into the pleural cavity to directly measuring the real pleural pressure. Exposure to the respiratory stimulant 4% CO₂, and intravenous administration of the histamine verified that this method was successfully investigated the process of respiratory changes and quantify the airway resistance and dynamic lung compliance. Comparison of the generating process of airway hyper-responsiveness in anaesthetizes dogs and conscious dogs showed that the respiratory function measurement in conscious dogs were more sensitive than in anaesthetizes dogs.

Author(s): Xinghan Song, Fei Liu, Jun Chen, Shanping Wang, Meiling Wen, Junhua Hu, Rui Zhang, Shuyao Zhan, Wen Tan
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