Biomedical Research

It is known that when cells are irradiated by ionizing radiation, not only the irradiated cells but also the surrounding non-irradiated cells are affected. This impact of Radiation-Induced Bystander Effect (RIBE) on non-irradiated cells has been widely studied; however, its implications in radiotherapy remain poorly understood. This study investigated RIBE in Non-Small Cell Lung Cancer (NSCLC), A549 cells and adjacent WI-38 cells following low-energy X-ray irradiation of the tumor cells. RIBE resulted in decreased viability of non-irradiated WI-38 cells co-cultured near irradiated A549 cells. In contrast, non-irradiated WI-38 cells enhanced the recovery of irradiated A549 cells via the Radiation-Induced Rescue Effect (RIRE). RIRE may be negligible as the advancements in radiotherapy technologies, including intensitymodulated radiation therapy and stereotactic body radiotherapy, which may enable the delivery of high-dose treatments in a single session. Further research is warranted to elucidate these mechanisms. Nevertheless, our findings elucidate the role of RIRE in irradiated tumors, which is important for optimizing the therapeutic outcomes of radiotherapy

Author(s): Ryosuke Seino, Mayuko Yoshikawa, Shun Saito, Kaori Tsutsumi, Hiroyuki Date
Abstract | PDF

Share this