Biomedical Research

Deficiency of Alpha-1 Antitrypsin deficiency (AAT) and higher CRP level are known biomarker for Lungs diseases. The purpose of this investigation was to estimate probable relations of AAT and CRP levels in the Lungs diseases. The sera of 27 patients of Emphysema, 20 patients with Chronic Obstructive Pulmonary Disease (COPD) and 17 patients of asthma along with 28 healthy volunteers were analysed. Age of patients and healthy volunteers was between 23 to 46 and male and female percentage was 71% and 29 % respectively. Serum AAT in asthma (0.401 ± 0.340), COPD (0.556 ± 0.310) and of emphysema (0.421 ± 0.311) is significant (P<0.001) lower than healthy control (1.01± 0.17). Serum CRP in asthma (3.930 ± 0.906), COPD (3.830 ± 0.666) and of emphysema (3.996 ± 1.049) is higher than healthy control (1.01 ± 0.17). Thus, serum AAT and CRP measurement can be helpful in predicting asthma control and treatment response.

Author(s): Desh Deepak Singh
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