Biomedical Research

Objective: To clinically evaluate the characteristics, treatment methods and outcome of Henoch- Schonlein purpura (HSP).

Methods: The clinical data, of 182 HSP children treated at Shaanxi Provincial People's Hospital in Xi’an, from January 2010 to October 2012, was collected and analyzed accordingly.

Results: (1) Majority of HSP sufferers were 7-14 years old (51.65%), followed by 4-6 years old (41.76%), and under 3 years of age (6.59%). Amongst them the school going children consisted of 132 patients (72.53%). (2) The first sign of HSP was palpable skin purpura, observed in a total of 117cases (48.34%) (3) Glucocorticoid therapy is significantly effective as 74 out of 79 (93.67%) cases of children treated by glucocorticoid therapy improved significantly.

Conclusions: HSP can present at any age, but is most common in school going children. More effective and aggressive treatment must be used to avoid the end-stage renal disease. Glucocorticoid treatment is effective for patients with severe abdominal pain and gastrointestinal bleeding, and the early short-term use of Prednisone results in quick recovery. Combined therapy with immune inhibitor is an appropriate therapeutic regimen for patients with nephrotic proteinuria.

Author(s): Fuyong Jiao, Bilal Haider Shamsi, Zhilong Mu, Na Gao, Yuan Fang, Ali Raza
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