Biomedical Research

Objective: To evaluate the relationship between carotid atherosclerosis and related risk factors.

Methods: Patients who were participant in neurology department of our hospital were selected for study. According to the ultrasound test results, 60 patients with carotid atherosclerosis were divided as the observation group, another 60 patients with normal carotid artery as the control group. All patients were subjected to following detection: bilirubin, Homocysteine (Hcy), C-reactive protein, Uric Acid (UA), blood lipids, blood pressure level. The test results were subjected to univariate and multivariate comparative analysis.

Results: After univariate comparative analysis, the history of diabetes, hypertension, alcohol consumption, smoking prevalence in the observation group was significantly higher, the difference was significant difference (P<0.005). After univariate comparative analysis, two DB, TB, Hcy, UA, High- Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C), Triglycerides (TG), Diastolic Blood Pressure (DBP), Systolic Blood Pressure (SBP), BMI comparative analysis, the difference was significant difference (P<0.05). After multiple regression analysis, according to the size of the contribution rate, from low to high was Hcy, history of diabetes, TG, LDL-C, smoking, hypertension, above risk factors and carotid atherosclerosis was positively correlated the HDL-C is a protective factor.

Conclusion: Carotid atherosclerosis is closely related to traditional risk factors for cardiovascular disease, the new risk factors can be defined as the assessment of atherosclerosis effective index.

Author(s): Xiaoyan Cao, Huayun Zhao, Wei Liu
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