Biomedical Research

Objective: To analyze the risk factors of acute hepatic damage in patients after open-heart surgery.

Methods: We selected 92 patients who underwent open-heart surgery for treatment in this hospital between July 2016 and July 2017 as the subjects who were then divided into two groups according to the onset of postoperative acute hepatic injury, i.e. the observation group (n=49) and the control group (n=43). Patients in the observation group experienced the onset of acute hepatic injury after surgery, but those in control group did not, and we evaluated the relevant risk factors of acute hepatic injury for patients after open-heart surgery.

Results: One-way analysis of variance showed that age (≥ 65 years), chronic viral hepatitis, preoperative right heart failure, excessively long time of extracorporeal circulation (≥ 2 h), blood products administration (≥ 1000 mL), low preoperative cardiac output, severe infection and hypoxemia were factors that could induce the acute hepatic injury in patients after open-heart surgery. According to the results of Logistic regression multivariate analysis showed that preoperative hepatic injury, excessively long time of extracorporeal circulation (≥2 h), blood products administration (≥ 1000 mL), low preoperative cardiac output, and hypoxemia were independent risk factors leading to the acute hepatic injury in patients after open-heart surgery.

Conclusion: The incidence of acute hepatic injury after open-heart surgery is correlated with the preoperative hepatic injuries and caused by the effects of various factors; thus, based on the comprehensive understanding on the relevant factors, we should maximally reduce the incidence rate of acute hepatic injury after open-heart surgery through correct clinical treatment.

Author(s): Sheng Wang, Huanzhou Xue, Zhaoyun Cheng, Ziniu Zhao, Shengkai Zhou
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