Biomedical Research

Objective: This study was designed to investigate the potential risk factors of cardiac metabolic abnormality in hypertension patients during the early stage.

Methods: In total, 1649 participants were enrolled in this clinical trial. Baseline data of all participants were collected and analysed. In the advanced-stage hypertension group, 530 patients diagnosed with hypertension were assigned, 562 patients with early-stage hypertension in the early-stage hypertension group and 557 with normal blood pressure in the control group. The potential risk factors of cardiac metabolic abnormality were statistically analysed in this case-control study.

Results: In the early-stage hypertension group, the blood pressure, age, Body Mass Index (BMI), waistline, serum levels of uric acid and hypersensitivity C-reactive protein were significantly higher, whereas the high-density lipoprotein cholesterol level was significantly lower compared with those in the control group (all P<0.05). Logistic regression analysis revealed that age and BMI were risk factors of the incidence of early-stage hypertension. In the advanced-stage hypertension group, 68.9% of patients were complicated with at least one metabolic disorder, and 52.0% in the early-stage hypertension group.

Conclusion: Age and BMI were risk factors of the incidence of early-stage hypertension. For early-stage hypertension patients, active measures should be implemented to prevent and treat the potential risk of cardiovascular metabolic disorders.

Author(s): Wang Yong, Cheng Jinsong, Huang Funing, Zhang Jianping, Xu Ding, Wang Shenghuang
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