Biomedical Research

Objective: To investigate the distribution, drug resistance and risk factors of Multi Drug Resistant Bacteria in diabetic foot infection (MDRMs), so as to provide reference for clinical prevention and treatment.

Methods: 96 cases of patients with diabetic foot infection were collected, and detection of pathogenic bacteria at infection site as well as analysis of drug sensitivity were conducted. 24 cases of MDRMs occurrence were seen as case group, and 32 cases of sensitive bacterial infection as control group, between which the comparative analysis of clinical data were conducted.

Results: The main MDRMs have a more serious resistance to common antibacterial drugs, and Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacteriaceae are relatively sensitive to meropenem, Pseudomonas and Enterobacteriaceae are relatively sensitive to aztreonam; the results of single factor and multi factor analysis showed that long-term use of antibiotics (OR: 1.747; 95% CI: 1.302~2.349), combination with osteomyelitis (OR: 4.287; 95% CI: 1.613~10.865), neural ischemic wound (OR: 1.238; 95% CI: 1.164~1.384 ), >2 times/y in hospital due to the same wound (OR: 1.953; 95% CI: 1.236~8.791) were independent risk factors that cause the occurrence of MDRMs (P<0.05).

Conclusion: When patients with diabetic foot infection are combined with MDRMs infection, Staphylococcus aureus, Pseudomonas aeruginosa and others are the most common. General resistance to a variety of cephalosporins, long-term use of antibiotics, combination with osteomyelitis, neural ischemic wound, >2 times/y in hospital due to the same wound are independent risk factors for the occurrence of MDRMs.

Author(s): Wan-Jun Kang, Lei Shi, Yan Shi, Lei Cheng, Hong-Wei Ai, Wen-Jun Zhao
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