Biomedical Research

The volatile oil of the coffee husk of Coffee arabica (Rubiaceae) was obtained by GCMS. This oil showed quorum sensing inhibition activity which were investigated for antipathogenic potential against P. aeruginosa (PAO1). The results showed that significant inhibition on the production of virulence P. aeruginosa and Biofilm Formation (BF). Moreover, the treatment with sub-MICs of coffee husk oil significantly inhibited the quorum sensing-mediated BF, extracellular polymeric substances production and swarming motility in these pathogens. Wide-spectrum in vitro inhibition of QS controlled virulence factors such as violacein, elastase, pyocyanin, EPS and biofilm in test pathogens was determined.

Author(s): Hanan M. Al-Yousef, Musarat Amina
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