Biomedical Research

Objective: To study the application value of Platelet Rich Fibrin (PRF) combined with atorvastatin in the regeneration treatment of degree II furcation involvements of mandibular molars.

Methods: Thirty patients with periodontitis (30 cases of degree II furcation involvements of mandibular molars) who underwent surgical treatment in our hospital from June 2015 to June 2016 were randomly divided into study group and control group, with 15 cases in each group (15 cases of degree II furcation involvements of mandibular molars). Both of the two groups were treated with periodontal Guided Tissue Regeneration (GTR) combined with bone graft, in which the study group was plus treated with Platelet-Rich Fibrin (PRF) combined with atorvastatin, and the control group was plus treated with PRF. Cone Beam Computed Tomography (CBCT) was used to evaluate the curative effect before and 6 months after this operation. The plaque index, gingival index and changes in clinical attachment loss were observed. The changes of IL-6 and TNF-α concentration in gingival crevicular fluid before and 6 months after operation were compared between the two groups.

Results: There were no significant differences in plaque index, gingival index, clinical attachment loss, CBCT metrics and IL-6 and TNF-α contents in the gingival crevicular fluid between the two groups (P>0.05) before the operation. Six months after operation, the plaque index, gingival index, clinical attachment loss, and IL-6 and TNF-α concentration in the gingival crevicular fluid in the study group were significantly lower than those in the control group (P<0.05). Compared with the control group, the CBCT metrics, vertical bone loss and horizontal bone loss, in the study group were significantly improved at baseline (P<0.05).

Conclusion: PRF combined with atorvastatin can effectively reduce the levels of IL-6 and TNF-α in gingival crevicular fluid and promote the effect of bone grafting in the treatment of degree II furcation involvements of mandibular molars, which is worth popularizing.

Author(s): Li Zhu, Mingwen Fan, Hongyi Zhang
Abstract | Full-Text | PDF

Share this