Biomedical Research

Objective: To assess the effect of the combination of abnormal cytology and High Risk Human Papilloma Virus (HR-HPV) test on preventing Cervical Intraepithelial Neoplasia (CIN) II+ and cervical cancer.

Methods: In the study, colposcopy examination and cervical biopsy were obtained and analysed from 206 women with abnormal cytology and positive/negative HR-HPV. The research grouping was according to cytological examination results.

Results: Among 206 cases, HR-HPV was positive in 45.15% (93/206), and CIN II+ 15.53% (32/206). And the HR-HPV positive rate of atypia squamous epithelial cells (ASCUS), Lower-Grade Squamous Intraepithelial Lesions (LSIL), and High-Grade Squamous Intraepithelial Lesions (HSIL)+ was 40.52% (62/153), 54.76% (23/42), 72.73% (8/l), respectively, with a statistical difference (χ2=6.1800, P<0.05). For the cervical biopsy finding of CIN II+, the overall predictive value of HR-HPV test was 87.50% in sensitivity and 56.90% in specificity, the positive predictive value 27.18%, and the negative 96.12%; for CIN III+, the overall predictive value of HR-HPV test was 100% in sensitivity and 51.50% in specificity, the positive predictive value 5.83%, and the negative 100%.

Conclusion: HR-HPV test can evaluate the risk of the finding of cervical cytology and guide its distributions, with extremely high sensitivity and negatively predictive value for CIN II+ and CIN III+.

Author(s): Jiang Li, Zuoliang Dong
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