Biomedical Research

Background: Vascular grafts are used common in surgery. Some patients have no native vessels for autograft so we should use vascular graft. In this study we assessed tissue reaction of rats to materials used in vascular grafts.

Materials and Methods: We prepared 8 types of grafts with electro-spinning method from different materials such as polycaprolactone (PCL), polyurethane (PU) and polyethylene terephthalate (PET) in sporadic and mixture patterns. After sterilisation with ethylene oxide, grafts were implanted in subcutaneous layer of 32 rats (divided into 8 groups of 4 rats). Rats assessed for local and general responses in 45 d. Histopathological responses were assessed by pathologist after 45 d.

Results: There is no mortality during study. There are no local and systemic responses. Surgical site Infection not found. Tissue reactions to polyethylene terephthalate (PET) was higher than PET (Bio). Tissue reactions to polyurethane (PU) and PU (Bio) were about equal. PU had lower reactions in comparison with (PET) and polycaprolactone (PCL). PU+PET (Bio) had lower reaction in comparison with PET+PCL (Bio)

Conclusions: It seems polyurethane has lesser reaction in compared with other materials in both single and mixture.

Author(s): Gholam Hosein Kazemzadeh, Nafiseh Jirofti, Davod Mohebbi-Kalhori, Reza Taheri
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