Biomedical Research

Objective: The occurrence of superimposed malignancies, which has been receiving increased attention, has been recognized as a severe side effect following successful malignancy therapy. The purpose of the study is to analyse the clinical features and etiological characteristics of superimposed malignancies in our hospital.

Material and Methods: In the last 10 years at our hospital, 40 patients have been diagnosed with hematopoietic malignancy superimposed with solid tumors. Their clinical characteristics and therapies were summarized. Cytogenetic analyses were performed using quinacrine fluorescence and trypsin- Giemsa banding techniques. Overall survival rates were estimated using the Kaplan-Meier method.

Results: Twenty-four patients developed solid tumors first and then secondary hematopoietic malignancy, 13 patients developed hematopoietic malignancy first and then secondary solid tumor, and 3 patients developed 2 malignancies at the same time. Here, we report that the recurring balanced translocations and primary chemotherapy were found in most of the patients first diagnosed with hematopoietic malignancies, and these patients had significant differences when compared with the patients first diagnosed with solid tumors (P=0.0134 and P=0.013, respectively). Moreover, the patients who were first diagnosed with hematopoietic malignancy had shorter survival times than those first diagnosed with solid tumors (P=0.026).

Conclusion: These data confirm and extend previous studies of clinical characteristics, treatments, cytogenetic and prognosis findings in superimposed malignancies.

Author(s): Yan Lin, Wei Wu, Weimin Dong, Xiaoying Hua, Yun Ling, Haiqian Li, Feng Yan, Shaoyan Hu, Xiaobao Xie, Weiying Gu
Abstract | Full-Text | PDF

Share this