Biomedical Research

Objective: To observe and evaluate the clinical efficacy of the intracavitary injection of triamcinolone acetonide for children with multiple tarsal cyst.

Methods: A retrospective study was performed. A total of 72 patients with multiple tarsal cyst recruited in our Eye Center from January 2013 to February 2015 were selected as the objects in which there were 30 girls and 42 boys at the age of 3 to 12 with the disease course ranging from 2 to 32 w. Cysts, 2-5 in number, were confined with no local tenderness. Among the involved cases, 42 patients had cysts with one eye and 30 with both eyes of which the cysts ulcerated through the skin in 28 cases. All patients were given intracavitary injection of triamcinolone acetonide. 0.4% oxybuprocaine was used for topical anesthesia with intracavitary injection of 0.05 to 0.1 ml triamcinolone acetonide suspension. Compression for 5 to 10 min was applied to stop bleeding. Injections were performed for each cyst. After one week, injections were performed again for cysts which was not completely absorbed with the topical injection for 1-2 times.

Results: In 44 cases of multiple cysts without skin ulceration, 7 d after the first injection there were 32 cases (72.73%) of complete absorption with no scar and 12 cases (27.27%) of incomplete absorption without scar in which 11 cases were complete absorption 1 w later without scar and 1 case was lost; By contrast, the marked absorption (100%) was found in all 28 cases of cysts with skin ulceration who were required the injection for the second time. 7 d after the second injection, there were 15 cases (53.57%) of complete absorption and 13 cases (46.43%) of incomplete absorption in which after 2 w 12 cyst cases were complete absorption without scar or pigment and 1 case was lost.

Conclusion: intracavitary injection of triamcinolone acetonide is worth being widely used in clinical trials due to its security and effectiveness in the treatment of children with multiple tarsal cyst.

Author(s): Ziyun Xiao, Yun You,Yuping Rao
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