Biomedical Research

Objective: This study aimed to investigate the clinical efficacy of statins in the prevention and treatment of coronary heart disease.

Methods: A total of 130 cases of patients with coronary heart disease were selected as research objects. These patients were admitted in our hospital from February 2015 to January 2017. All patients with coronary heart disease were randomly divided into two groups as follows: control group (n=65), undergoing the conventional therapy of coronary heart disease; observation group (n=65), undergoing the conventional therapy+pravastatin/simvastatin. Finally, the efficacies, blood lipid improvement results, treatment satisfaction survey results, and adverse reactions of patients were compared between the two groups.

Results: The efficacy of patients with coronary heart disease in the observation group was significantly increased (98.46%) compared with that in the control group (80%) (P<0.05). The blood lipid of patients with coronary heart disease in the observation group was also significantly improved (P<0.05). The treatment satisfaction survey results of patients with coronary heart disease in the observation group were also significantly improved (98.46%) compared with that in the control group (84.62%) (P<0.05). Furthermore, the incidence of adverse reactions of patients with coronary heart disease in the observation group was significantly reduced (3.08%) compared with that in the control group (18.46%) (P<0.05).

Conclusion: During the prevention and treatment of coronary heart disease, the rational application of statins can improve the efficacy, blood lipid level, therapy satisfactions, and therapeutic safety so as to alleviate the coronary heart disease and improve the overall efficacy.

Author(s): Qiang Chen, Li-Zhu Chen, Xiao-Hua Guo, Juan Zhang
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