Biomedical Research

Objective: To evaluate the clinical efficacy of ultrafiltration for Acute Decompensated Heart Failure (ADHF) with diuretic resistance.

Methods: Totally 120 patients with ADHF combined with diuretic resistance were enrolled in Affiliated Hospital of Nantong University. According to the treatment methods, 62 cases were included the observation group and 58 cases included the control group. The control group received conventional therapy, while the observation group received blood ultrafiltration and then compared the differences of clinical efficacy.

Results: The heart rate and respiratory rate of the observation group were significantly lower than those in the control group (80.04 ± 15.60 vs. 91.27 ± 16.75, P<0.05) and (22.36 ± 1.82 vs. 25.67 ± 1.28, P<0.05), the oxygen saturation of the observation group was significantly higher than that of the control group (94.42 ± 1.87 vs. 91.31 ± 1.54P<0.05). The serum creatinine and Brain Natriuretic Peptide (BNP) of the observation group were significantly lower than those in the control group (213.54 ± 57.46 vs. 301.52 ± 78.33, P<0.05), (520.57 ± 62.10 vs. 612.41 ± 78.50, P<0.05), the volume of 24 h urine of the observation group were significantly higher than those in the control group (1085.47 ± 145.63 vs. 910.44 ± 120.63, P<0.05).

Conclusion: The ultrafiltration treatment for ADHF with diuretic resistance can improve the patients' heart and kidney function and prognosis, increase the urine volume and decrease the level of serum BNP, which is worthy of clinical application.

Author(s): Jian Zhang, Qi Lu
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