Biomedical Research

This study aims to assess the efficiency and safety of intra-arterial thrombolysis treatment for wake-up stroke under the supervision of CT perfusion (CTP). 12 wake-up stroke patients fit for intra-arterial thrombolysis were checked with CTP before thrombolysis treatment; cranial CTP was checked after treatment. Neural function defect scores (NIHSS), Barthel Index (BI) of activity of daily life (ADL) and mRS scores were evaluated at 6 hour and 7 day after thrombolysis treatment. Results found that, the cranial CT at 24 hour after thrombolysis showed HI-1 type hemorrhage in 2 patients and HI-2 hemorrhage in 1 patient. No PH-1 or PH-2 hemorrhage was observed. At 7 day after thrombolysis the hypoperfusion was greatly improved. Before thrombolysis, the NIHSS, ADL (BI) and mRS of 12 patients were 12.0 ± 4.0, 45.4 ± 16.0 and 3.7 ± 0.8, respectively. At 6 hour after thrombolysis, the NIHSS, ADL (BI) and mRS were 2.0 ± 2.1, 85.4 ± 16.0 and 0.6 ± 0.9, respectively, which were significantly different with before thrombolysis (P < 0.05). At 7 day after thrombolysis, the NIHSS, ADL (BI) and mRS of 12 patients were 0.4 ± 0.8, 95.5 ± 8.4 and 0.3 ± 0.8, respectively, which were highly significantly different with before thrombolysis (P < 0.01). CTP can be applied for intra-arterial thrombolysis treatment of wake-up stroke, with definite efficacy and safety.

Author(s): Peng Wang, Hong-Jian Guan, Zhi-Min Wang, Cheng-Hua Xu
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