Biomedical Research

Objective: To compare and analyze the differences among the early gastric cancer patients receiving laparoscopy and those receiving open radical gastrectomy in prognosis and survival rate.

Methods: controlled trials were used for analysis and comparison. 200 cases of early gastric cancer patients received and cured by the general surgery department of the Hospital between 2012 and 2015 were randomly selected as research and observation objects. With the method of random grouping, 200 patients were divided into the laparoscopy group and the open surgery group. Each of them contained 100 cases of patient. Among them, the patients in the laparoscopy group received laparoscopy radical gastrectomy for treatment and the patients in the open surgery group received open radical gastrectomy for treatment. Operation time, intraoperative blood loss volume, ventilation duration, hospital stay, postoperative life quality of the patients, and one-year, three-year and five-year survival rate respectively were set as the indicators for clinical evaluation to compare these two groups of patients.

Results: The operation time (168.23 ± 28.36) of the patients in the laparoscopy group was significantly longer than that (134.56 ± 27.57) of the patients in the open surgery group (P<0.05), and the difference was statistically significant; the intraoperative blood loss volume (131.68 ± 26.68 mL) of the patients in the laparoscopy group was significantly lower than that (178.36 ± 35.66 mL) of the patients in the open surgery group (P<0.05), and the difference was of statistical value; the hospital stay (9.36 ± 1.35 d) of patients in the laparoscopy group was significantly shorter than that (12.32 ± 1.65 d) of the patients in the open surgery (P<0.05), and the difference was statistically significant; the ventilation duration (2.65 ± 0.32 d) of the patients in the laparoscopy group was significantly shorter than that (4.72 ± 1.42 d) of the patients in the open surgery (P<0.05), and the difference was statistically significant; the postoperative life quality (scoring 48.35 ± 6.64 points) of the patients in the laparoscopy group was significantly higher than that (scoring 78.46 ± 6.59 points) of the patients in the control group (P<0.05), and the difference was statistically significant; there was no significant differences in the one-year, twoyear and three-year survival rate between the two groups, and the difference was not statistically significance.

Conclusion: compared with the open radical gastrectomy, the laparoscopy radical gastrectomy has the advantages including small trauma, less pain, and faster improvement of postoperative life quality. Besides, its postoperative survival rate is similar to that of the traditional radical gastrectomy. Therefore, it is worthy to be promoted and referred in clinic practices.

Author(s): Lei Zhou, Guochao Zhang, Jixi Liu, Haibin Liu, Chaofeng Li
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