Biomedical Research

Objective: To compare and analyse the effect of 3D intensity-modulated radiation therapy and 3D conformal radiation therapy concurrently combined with chemotherapy for stage III (staging of tumor node metastasis) non-small cell lung cancer.

Methods: A total of 100 patients with stage III non-small cell lung cancer who were treated in our hospital from May 2015 to July 2016 were selected as the objects and randomly divided into observation group and control group with 50 cases in each group. The control groups were treated with conformal radiotherapy combined with chemotherapy while the observation groups were given 3D conformal radiation therapy concurrently combined with chemotherapy. Adverse reactions, content of tumor markers and clinical effect were compared between the two groups.

Results: After treatment, the total effective rate of the observation group (62%) was obviously higher than that of the control group (48%) of statistical significance, P<0.05. And the adverse reactions in the observation group were less than those in the control group (P<0.05). The contents of Cyfra21-1, SCC and TSGF decreased in both two groups but the contents in the observation group were significantly lower than those in the control group of statistical significance (P<0.05).

Conclusion: Three dimensional intensity-modulated radiation therapy combined with chemotherapy has a good therapeutic effect. It can lower adverse reactions and reduce serum tumor markers in the patients with very high value in clinical practices.

Author(s): Changqing Sun, Lingjun Meng, Zhongfei Yang
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