Biomedical Research

Objective: To compare and analyse the effect of alendronate sodium gel and simvastatin gel topical administration in the treatment of mandibular molar furcation involvements.

Methods: A total of 80 patients with mandibular molar furcation involvement treated in our hospital were selected as cases from March 2015 to January 2017. They were randomly divided into groups A and B, 40 cases in each group. Both groups were treated with ultrasound, in which group A was treated with topical administration of alendronate sodium gel and group B was treated with topical administration of simvastatin gel. Gingival Index (GI), Sulcus Bleeding Index (SBI), Bleeding on Probing (BOP), Probing Depth (PD), Probing Pyorrhea (POP), clinical curative effect and level changes of TNF- alpha, IL-1 beta and LPS in gingival crevicular fluid were measured in both groups before the treatment and 4 weeks after it.

Results: There was no significant difference in the levels of PD, SBI, GI, BOP and POP between the two groups before treatment. The levels of PD, SBI, GI, BOP and POP in group B were significantly higher than those of group A after 4 w of treatment. The levels of TNF-α, IL-1β and LPS in gingival crevicular fluid of two groups showed no significant difference before treatment. The levels of TNF-α, IL-1β and LPS of group B were significantly lower than those of group A after treatment. The total effective rate of group B was 95%, which was significantly higher than that of group A after 4 w of treatment (82.5%). The difference was statistically significant.

Conclusion: Compared with alendronate sodium gel, clinical effect of topical administration of simvastatin gel in the treatment of mandibular molar furcation involvements is more significant. It can not only improve the gingival index, sulcus bleeding index and other clinical indicators, but also reduce TNF-α, IL-1β and LPS levels in gingival crevicular fluid, deserves further application and promotion.

Author(s): Li Zhu, Mingwen Fan, Hongyi Zhang, Wei Li, Xiaowei She
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