Biomedical Research

Aim: This study aimed to explore the clinical efficacy of Intravitreal injection of Conbercept (IVC) in Diabetic Macular Edema (DME) based on the morphological pattern on Optical Coherence Tomography (OCT).

Methods: In total, 111 cases (115 eyes) with DME were enrolled. They were classified into three groups based on their OCT patterns: Diffuse Retinal Thickening (DRT), Cystoid Macular Edema (CME), and Serous Retinal Detachment (SRD). All cases were treated with IVC (0.05 mg/0.01 ml). The central foveal thickness was measured using OCT. The proportion of capillary nonperfusion was assessed using OCT angiography.

Results: The 115 eyes consisted of 34 DRT, 47 CME, and 34 SRD cases. After IVC, the central foveal thickness in all the groups reduced, and the best-corrected visual acuity increased. The baseline of the DRT group was better than that of the other two groups. The SRD reaction was poor after IVC, and significant differences were found between SRD and DRT or CME. SRD showed statistical significance, but CME and SRD had no significance after 12 months. Foreign body sensation was found in 17/111 cases, conjunctival congestion in 9/111 cases, subconjunctival hemorrhage in 22/111 cases, and postoperative intraocular pressure elevation in 2/111 cases after 12 months. The size of the foveal avascular zone and total avascular area were the same or even greater in eyes with diabetic retinopathy after IVC treatment.

Conclusions: IVC is effective in all three morphological patterns on OCT with fewer complications. In this study, the DRT group showed the best effect.

Author(s): Xiao-Qing Li, Xu-Xia Meng, Feng-Lei Wang, Yu-Dong Fu
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