Biomedical Research

Objective: Correlation of vaginal micro-ecology and human papilloma virus infection to cervical lesions.

Methods: From May 2014 to May 2017, 40 patients with cervical lesion enrolled in our hospital were collected and set as the research group. Meanwhile, another 40 patients without the lesion were collected in the control group. Patients in both groups were given determinations of vaginal flora followed by further detection of the high-risk Human Papilloma Virus (HPV). The correlation between HPV and the result of vaginal flora determinations in both groups was analysed with the logistic regression model.

Results: The rate of micro-ecological imbalance in the research group was higher than that in the control group (P<0.05). There was no significant difference in the detection rate of Trichomonas infection between these two groups (P>0.05). The detection rate of Lactobacilli, Candida and lead cells between these two groups turned out to be significantly different (P<0.05). In addition, the positive rate of HPV in the research group was significantly higher than that in the control group (P<0.05). The logistic regression model analysis showed that the independent risk factors of cervical lesions included HPV infection, lactobacillus and vaginal micro-ecological imbalance.

Conclusion: There are many characteristics in the case of cervical lesions, including significant vaginal imbalance, lower detection rate of Lactobacilli and positive rate of HPV.

Author(s): Ting Qiu, Qiuxian Mao
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