Biomedical Research

Objective: This study attempts to analyse the curative effect of Continuous Renal Replacement Therapy (CRRT) on patients with septicopyemia and acute kidney injury and its influence on serum inflammatory factors.

Methods: A total of 96 cases with septicopyemia and acute kidney injury at our hospital from January 2014 to June 2016 were collected. These cases were then divided into the observation (n=48) and control groups (n=48) by the random number method. The control group was administered with conventional therapy, whereas the observation group was administered with CRRT therapy based on the conventional therapy. The curative effects on the two groups were then compared.

Results: The observation group exhibited a significantly better therapeutic effect than the control group (P<0.05). The two groups had no significant differences in their IL-1β, IL-6, TNF-α, PCT, and CRP levels before the treatment, which showed no statistical significance (P<0.05). The IL-1β, IL-6, TNF-α, PCT, and CRP levels of both groups then decreased sharply after the treatment (P<0.05). The IL-1β, IL-6, TNF-α, PCT, and CRP levels of the observation group were significantly lower than those of the control group (P<0.05).

Conclusions: CRRT can effectively decrease the levels of serum inflammatory factors of patients with septicopyemia and acute kidney injury, as well as improve the inflammatory reactions of patients. Thus, CRRT can be widely applied because of its promising clinical therapeutic effects.

Author(s): Yong-Bo Lin, Ling Zhou
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