Biomedical Research

Introduction: The presented case highlights the challenges in managing refractory LGS and the limited efficacy of current treatments. DBS targeting the centro-medial thalamus shows potential in reducing seizure frequency and improving electrographic activity in LGS patients.

Case presentation: This case report presents the use of Deep Brain Stimulation (DBS) targeting the centro-medial thalamus as potential therapeutic approach for a patient with refractory Lennox-Gastaut Syndrome (LGS), who did not achieve seizure reduction on multiple anti-seizure medications and vagus nerve stimulation.

Results: The findings from this case suggest that targeting the centro-medial thalamus with Deep Brain Stimulation (DBS) a potential intervention for managing refractory Lennox-Gastaut Syndrome (LGS) and achieving seizure freedom.

Conclusion: Future research should focus on conducting randomized controlled trials to establish DBS as a standard treatment for LGS. Careful consideration of the benefits, risks, and long-term outcomes of DBS, along with adherence to patient selection criteria, will be important. Collaboration and evidence accumulation through additional cases and centres can further enhance the understanding of DBS as a viable therapeutic option for this severe and debilitating epileptic condition.

Author(s): Awadh M. Alahmari, Ebia Samkari, Ahmad Khani, Ashraf Alharthi
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