Biomedical Research

Background: Recovering blood flow to a coronary stenosis may improve left ventricular (LV) function in patients with coronary artery disease (CAD). However, the reported data about evaluation of LV function post-percutaneous coronary intervention (PCI) in CAD was limited. Purpose of this study was to compare the LV function measured by ejection fraction (EF) and global longitudinal strain in patients with CAD underwent PCI, and to identify factors affecting the change of LV function.

Methods: Patients with CAD who underwent elective PCI were enrolled. Echocardiographic measurements of LV function by EF as well as by 2D speckle tracking to assess global longitudinal strain were performed in all patients within 24 hours pre- and post-PCI procedure. The LV global longitudinal peak strain average (GLPS-Avg) was calculated from 18 segments measurement.

Results: A total of 40 patients (55.9 ± 7.5 y.o.) were enrolled. Means of GLPS-Avg pre- and post-PCI were -12.41 ± 4.82% and -13.41 ± 4.94%, respectively. Means of EF pre- and post-PCI were 43.2 ± 11.0% and 45.6 ± 11.7%, respectively. The improvement of LV function was more significant statistically when it was measured by GLPS-Avg (p<0.0001) than that of EF (p<0.001). The improvement of GLPSAvg was correlated with target vessel revascularization involving non-left anterior descending artery (p=0.00, coefficient correlation=0.484).

Conclusions: Recovery of left ventricular function could be detected early post-revascularization of coronary artery disease by either ejection fraction or global longitudinal strain measurements; however the latter is more accurate. Improvement of GLPS is correlated moderately with target vessel revascularization involving non-left anterior descending artery.

Author(s): Sodiqur Rifqi, Safir Sungkar, Mochamad Ali Sobirin, Ilham Uddin, Yoshiyuki Furuse, Mochamad Arif Nugroho, Udin Bahrudin, Ichiro Hisatome
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