Biomedical Research

Objective: To investigate the effects of baihu ginseng decoction on intestinal microflora structure in type 2 diabetic rats.

Methods: Total 60 type 2 diabetic SD rats were randomly divided into three groups, including model group, gliclazide group and baihu ginseng decoction group. In the gliclazide group, rats were treated with gliclazide lavage, while rats in baihu ginseng decoction group were treated baihu ginseng decoction lavage. After 2 w, the level of blood glucose, blood lipid, glucose tolerance, glycosylated Hemoglobin (HbA1c) and insulin in all rats were measured and analysed. Meanwhile, the change of intestinal microflora structure in stool samples were detected with quantitative PCR.

Results: Baihu ginseng decoction could help decrease the concentration of blood glucose, cholesterol and triglyceride obviously in diabetic rats, increase the diabetic rats’ High Density Lipoprotein Cholesterol (HDL-C) and the levels of Lactobacillus and Bifidobacterium.

Conclusion: Baihu ginseng decoction has significant effects on reducing blood glucose and blood lipids. Its hypoglycemic effect may be related to the community of Lactobacilli and Bifidobacterium.

Author(s): Kaijian Hou, Weijie Zhong, Chao Chen, Bangtai Wu, Dan Zhu, Xuhuang Wang, Yuanyuan Guo
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