Biomedical Research

Objective: Many cancer patients suffered from mental disorders. This research was to investigate the effect of comprehensive nursing intervention on patients with breast cancer.

Method: Patients were accepted routine nursing in control group (group C), and comprehensive nursing intervention in intervention group (group I). At the end of the operation and in the following two months after operation, the levels of depression, anxiety, life quality, and sleep quality were evaluated, and the expressions of Lactic Dehydrogenase (LDH), α-fetoprotein (AFP) and Carcino-Embryonic Antigen (CEA) were also detected. The rates of recurrence and metastasis were assessed during 3-year follow-up.

Results: The levels of depression and anxiety of patients in group I were much higher than group C (P<0.05). Life and sleep qualities in both groups were improved, while the quality in group I was significantly better than group C (P<0.05). The expressions of LDH, CEA and AFP of patients in both groups were reduced, while the reduction in group I was more significant than group C (P<0.05). After 3-year follow-up, the recurrence and metastasis rates in group I were significantly lower than group C (P=0.044, P<0.05).

Conclusions: Comprehensive nursing intervention contributed to the improvement of life quality, sleep quality and mental health, and was helpful to improve the therapeutic effect of breast cancer.

Author(s): Xia Kang, Yu Fang, Yu Kong
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