Biomedical Research

Objective: To investigate the effect of dezocine combined with propofol on pain mediators, inflammatory reaction and immune response indexes in patients undergoing colonoscopy.

Methods: 96 cases undergoing colonoscopy in our hospital from March 2016 to March 2017 were randomly divided into observation group (48 cases, anesthetized by dezocine combined with propofol) and control group (48 cases, anesthetized by sole propofol). The expression of 5-Hydroxytryptamine (5- HT), Dopamine (DA), Norepinephrine (NE), prostaglandin (PGE2), Substance P (SP), tumor necrosis factor -α (TNF-α), Interleukin (IL)-1β, IL-6, IL-8, C-Reactive Protein (CRP) in serum, and the counts of Th1 cells and Th2 cells of all cases were detected respectively before and 30 min after colonoscopy.

Results: The time of insertion and retreat of colonoscopy of the observation group was obviously shorter, and the incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). There were no significant differences in laboratory indexes between 2 groups before colonoscopy (P>0.05). 30 min after colonoscopy, 5-HT, DA, NE, PGE2, SP, TNF-α, IL-1β, IL-6, IL-8, CRP in all patients increased markedly and the intragroup differences had statistical significance (P<0.05). The above indexes in the observation group were significantly lower than those in the control group (P<0.05). There were no significant changes in Th1 and Th2 in 2 groups (P>0.05).

Conclusion: Dezocine combined with propofol in anaesthesia for colonoscopy can inhibit the increase of pain mediators and inflammatory reaction indexes and will not affect patients’ immune function. It may help to shorten the examination time and reduce adverse reactions.

Author(s): Xiao-ya Zang, Xiao-juan Xie, Ping Feng
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