Biomedical Research

Objective: To observe the application value of laparoscopic surgery in the treatment of endometrial carcinoma, and its influence on the level of serum tumor markers such as YKL-40, SCCAg, CYFRA21-1 and serum inflammatory factors such as hs-CRP, TNF-α, IL-4.

Methods: From January 2015 to May 2016, a total of 120 patients with endometrial carcinoma were enrolled in our hospital and divided into control group (n=60) and study group (n=60) randomly. Patients in control group were treated with conventional laparotomy and patients in study group were treated with laparoscopic surgery. The level of serum YKL-40, SCCAg, CYFRA21-1 and hs-CRP, TNF- α and IL-4 were measured by ELISA and then compared. The therapeutic effects of the two groups were also observed and compared.

Results: Before treatment, there was no significant difference in serum YKL-40, SCCAg and CYFRA21-1 between the two groups. After treatment, the values of serum YKL-40, SCCAg and CYFRA21-1 in the study group were significantly lower than those in the control group. Before treatment, there was no significant difference in serum hs-CRP, TNF-α and IL-4 between the two groups. After treatment, the values of serum hs-CRP, TNF-α and IL-4 in the study group were significantly lower than those in the control group. The total effective rate of the study group was 93.3%, significantly higher than 86.7% of the control group. All 120 patients were followed up from the shortest follow-up period of one month to the longest of 12 months, with no recurrence or postoperative complication in the study group, while one vaginal recurrence case in the control group who received radiotherapy.

Conclusion: Laparoscopic surgery was superior to conventional laparotomy for patients with endometrial carcinoma for reducing values of serum YKL-40, SCCAg, CYFRA21-1, hs-CRP, TNF-α, IL-4 and recurrence rate effectively, which worthy of promotion and application.

Author(s): Shaoguang Wang, Yaozong Dong, Xiaomei Meng
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