Biomedical Research

Objective: To observe the effect of percutaneous transforaminal lumbar spine endoscopic discectomy on lumbar disc herniation and its influence on indexes of oxidative stress.

Methods: A total of 110 patients with lumbar disc herniation from May 2015 to May 2016 in our hospital were divided into control group (n=50) and study group (n=60) according to different surgical programs, with control group treated with traditional open discectomy and study group treated with percutaneous transforaminal lumbar spine endoscopic discectomy. Operation related indexes were compared between the two groups as well as ODI and VSA scores, serum inflammatory factors and indexes of oxidative stress before the operation and three months later.

Results: There was no significant difference in operation time between the two groups. The amount of blood loss, the size of incision and bedtime in the study group were better than those in the control group (P<0.05). Compared with preoperative, the ODI and VAS scores of the two groups were both significantly decreased at the end of three months later, but the study group decreased more than the control group (P<0.05). There was no significant difference in serum inflammatory factors TNF-α and CRP or indexes of oxidative stress such as MDA, MPO, SOD and TAC between the two groups before operation (P>0.05), while the values of serum TNF-α and CRP in the study group significantly lower than those in the control group (P<0.05), the values of MDA, MPO in the study group significantly lower than those in the control group (P<0.05), and the values of SOD, TAC in the study group significantly higher than those in the control group at the end of three months later (P<0.05).

Conclusion: It is well worth promoting and applying percutaneous transforaminal lumbar spine endoscopic discectomy in clinic for its’ advantages in less trauma, less blood loss and quicker postoperative recovery, which can improve the patients’ dysfunction, reduce the pain and values of serum inflammatory factors, improve the level of indexes of oxidative stress, and then improve the effect of surgery notably.

Author(s): Hongguang Wang, Yang Song, Liyang Cai
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