Biomedical Research

Objective: This paper aims to discuss the effect of peripheral blood T-lymphocyte subpopulation test on gastric cancer monitoring and prognostic evaluation.

Methods: Ninety-three patients with gastric cancer were recruited for this prospective study and randomly divided into two groups. The conventional treatment group was treated with DDP+5- trihydroxypyrimidine, and the observation group was treated with combined raltitrexed and oxaliplatin. Venous blood samples were collected on an empty stomach before and after the treatment. The proportions of Th1 and Th2 were determined by flow cytometry analysis. Serum levels of IL-2 and IL-10 were tested by an enzyme-linked immunosorbent assay kit. Another 33 volunteer patients were recruited in the same period for the control group.

Results: Before the treatment, the conventional treatment group and the observation group possessed higher proportions of Th1 and Th2 and serum levels of IL-2 and IL-10 but significantly lower Th1/Th2 and IL-2/IL-10 than the control group (P<0.05). However, the difference between the conventional treatment group and the observation group was not statistically significant (P>0.05). After the treatment, the observation group exhibited lower proportions of Th1 and Th2 and serum levels of IL-2 and IL-10 but higher Th1/Th2 and IL-2/IL-10 than the conventional treatment group (P<0.05).

Conclusions: Peripheral blood T-lymphocyte subpopulation test can be used as an index for gastric cancer monitoring and prognostic evaluation and merits clinical promotion.

Author(s): Ting Lv, Cai-Yun Zhang, Lei Dong, He-Ping Wu
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