Biomedical Research

Objective: To investigate the effect of specific immunotherapy induced by Dermatophagoides farinae on treatment of children with combined allergic rhinitis and asthma syndrome.

Methods: From January 2014 to January 2016, 100 cases of children with combined allergic rhinitis and asthma syndrome enrolled in our hospital were selected as the objects. All children were randomly divided into two groups with 50 cases in each group. The patients in the control group were treated with glucocorticoid inhaled. Meanwhile, the patients in the observation group received specific immunotherapy followed by inhaled corticosteroid. Twelve months later, rhinitis control effect, rhinitis symptoms scores, asthma symptom scores and pulmonary function index were analysed and compared between those two groups.

Results: The total effective rate of rhinitis control in the observation group was higher than that in the control group. However, the score of rhinitis symptom in the observation group was lower than that in the control group. The total effective rate of asthma control in the observation group was higher than that in the control group. After treatment, the indexes of pulmonary ventilation function of the two groups were both significantly improved. But, the indexes of pulmonary ventilation function in the observation group were better than those in the control group.

Conclusion: In treatment of children with combined allergic rhinitis and asthma syndrome, specific immunotherapy can effectively control the symptoms of rhinitis and asthma, help to control progression of the disease and significantly improve the lung function of the children.

Author(s): Deli Wang, Enqin Zhang, Erbin Xiao
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