Biomedical Research

Objective: Neonatal hyperbilirubinemia (N-HB) usually resulted in bilirubin encephalopathy even death in children. The present study was designed to investigate the prevention and intervention initiatives for N-HB.

Materials and Methods: Case-control method was used to study the effects of early intervention on neonate with hyperbilirubinemia and perinatal factors. A total of 412 N-HB cases (209 were boys and 203 were girls) in Weihai Municipal Hospital were divided into intervention group and control group and five important perinatal factors were observed including intrauterine pneumonia, neonatal asphyxia, cephalohematoma, polycythaemia and maternal diabetes. The effectiveness of early intervention by greater or fewer than 75% position was determined.

Results: The results showed that the interventions with enema containing glycerol and saline significantly reduced the bilirubin levels in serum from birth to 96 hours after birth compared with control group (P<0.05). In addition, five factors showed the significance between two groups respectively (P<0.05).

Conclusions: Early intervention significantly decreased the hyperbilirubinemia incidence of neonate. These measures were easy to be taken.

Author(s): Jinfen Han, Xuegong Liu, Fengjuan Zhang
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