Biomedical Research

Objective: To investigate the effects of Percutaneous Nephroscope Ultrasonic Lithotripsy (PNUL) and Percutaneous Nephroscope Pneumatic Lithotripsy (PNPL) on stress hormones, vascular inflammatory factors and tissue damage inflammatory factors in patients with renal calculi.

Methods: 120 patients with renal calculi in our hospital from January 2016 to June 2017 were divided randomly into observation group (PNUL group) and control group (PNPL group), 60 cases in each group. At 24 h before and after operation, the levels of Angiotensin-II (Ang-II), Adrenocorticotropic Hormone (ACTH), Cortisol (Cor), Norepinephrine (NE), Prostaglandin E2 (PEG2), Substance P (SP), Bradykinin (BK), Nitric Oxide (NO), Advanced Oxidation Protein Products (AOPP) and Lipid Peroxide (LPO) were compared in all patients.

Results: There were no statistical differences in the levels of Ang-II, ACTH, Cor, NE, PEG2, SP, BK, NO, AOPP and LPO before operation between the two groups (P>0.05); at 24 h after operation, the level of each index was higher than that before operation in both groups. The levels of above-mentioned indexes in the observation group were (53.38 ± 4.65 pg/ml), (27.28 ± 3.06 pg/ml), (172.76 ± 10.65 ng/ml), (276.19 ± 24.12 ng/ml), (161.51 ± 16.70 pg/ml), (4.71 ± 0.51 μg/ml), (8.32 ± 0.64 μg/L), (13.42 ± 1.56 μmol/L), (202.38 ± 31.74 μmol/L), (4.29 ± 0.63 mmol/ml) respectively, were lower than those during the same period in the control group and the differences were statistically significant (P<0.05).

Conclusion: PNUL has a less effect on stress hormones, vascular inflammatory factors, tissue damage inflammatory factors in patients with renal calculi and has a smaller trauma than PNPL. Thus, PNUL is recommended to be widely used in clinical practice.

Author(s): Shang-wen Xiao, Fu Shi, Bao-hai Xu
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