Biomedical Research

Objective: This study was aimed to explore effects of domperidone combined with doxepin hydrochloride in treatment of functional dyspepsia.

Methods: From Aug 2015 to Feb 2017, 100 patients with functional dyspepsia were selected from Yuyao People’s Hospital as the study subjects and were randomly divided into control group (n=50) and experimental group (n=50) in which patients in the control group were treated with conventional drugs treatment of domperidone while patients in the experimental group received domperidone treatment combined with doxepin hydrochloride. Clinical effects in two groups were observed.

Results: Treatment efficiency of the experimental group was significantly higher than that of the control group (P<0.05), the degree of anxiety and depression of the experimental group is lower than that of the control group after treatment (P<0.05) with no significant difference (P>0.05). The scores in such clinical symptoms as stomach pain, bloating, stomach burning and belching, the incidence of adverse effect and recurrence rate of the experimental group were significantly lower than that of the control group (P<0.05).

Conclusion: Domperidone combined with doxepin hydrochloride has notable effects in treatment of functional dyspepsia and possesses application value due to its function of improving clinical symptoms, effectively reducing the incidence of adverse effect and recurrence rate and enhancing activity daily living of the patients.

Author(s): Qifeng Song, Jianbo Zhou, Jianzhong Sang
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