Biomedical Research

Objective: To investigate the effects of High Flux Hemodialysis (HFHD) on oxidative stress, microinflammatory state and cellular immune function in patients with diabetic nephropathy and hemodialysis.

Methods: From March 2016 to March 2017, 90 Elderly Patients with Diabetic Nephropathy and Hemodialysis in our hospital were selected as the research objects and divided into group A and B according to the different treatment, with 45 cases in each group. HFHD was performed in group A while Low Flux Hemodialysis (LDHD) was performed in group B. Before and after treatment, the expression levels of Superoxide Dismutase (SOD), Glutathione Peroxidase (GSHPx), Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-α), High Sensitive C-reactive protein (HS-CRP) and the changes of peripheral blood T lymphocyte subsets were checked and compared between those two groups.

Results: Before treatment, there was no significant difference in serum oxidative stress factors of SOD and GSHPx between the two groups. After treatment, the levels of serum oxidative stress factors of SOD and GSHPx in group A were increased significantly and higher than those in group B. Before treatment, no significant differences of serum micro-inflammatory factors of IL-6, TNF-α, hs-CRP were found between the two groups. After treatment, however, the expression levels of IL-6, TNF-α, hs-CRP were significantly reduced and lower than those in group B. Before treatment, no significant differences of peripheral blood T lymphocyte subsets of CD3+, CD4+, CD8+, CD3+/CD8+ were found between the two groups. After treatment, the expression of CD3+, CD4+ and CD4+/CD8+ in group A was significantly increased and higher than that in group B. However, there was no significant difference in the expression of CD8+ between the two groups.

Conclusion: The implementation of HFHD treatment in elderly patients with Diabetic Nephropathy and Hemodialysis could effectively improve the oxidative stress, micro-inflammatory state and cellular immune function. It had great value and was worthy of popularization and application.

Author(s): Junyue Huang, Shouyan Lu
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