Biomedical Research

Objective: To investigate the clinical effect of alendronate on osteoporosis and its effect on Cyt C, Apaf-1 and caspase-9.

Methods: 100 cases of bone fracture patients diagnosed as osteoporosis in the hospital from January 2014 to December 2016. After fracture fixation, the patients were randomly divided into control group and observation group. The control group with 50 cases was given Calcium and observation group with 50 cases were treated with alendronate on the basis of the control group. The bone pain degree, bone mineral density and bone biochemical indexes of the two groups were recorded and compared. The cytochrome C (Cyt C) and Apoptotic Protease activating Factor-1 (Apaf -1) and caspase-9 levels of the two groups was compared.

Results: After treatment, the bone mineral density of both groups significantly increased, and the score of bone pain significantly decreased (P<0.05). After treatment, the bone mineral density of the observation group was significantly higher than that of the control group, and the visual score of bone pain was significantly lower than that of the control group (P<0.05). The level of serum osteocalcin in the observation group significantly increased and was significantly higher than that in the control group after treatment (P<0.05). The level of serum NTX in the observation group significantly decreased and was significantly lower than that in the control group after treatment (P<0.05).The serum calcium in both groups significantly increased after treatment (P<0.05). The proportion of urinary calcium/ creatinine in the observation group was significantly lower than that in the control group after treatment. The levels of Cyt C, Apaf-1 and caspase-9 in the bone tissue of the observation group were significantly lower than those in the control group after treatment (P<0.05). In terms of safety, the incidence of adverse reactions was not significant differences (P>0.05).

Conclusion: Sodium alendronate can effectively ease the bone pain in osteoporosis patients, improve bone density, improve bone metabolism, and reduce the levels of apoptosis-related factors Cyt C, Apaf-1 and caspase-9 in bone tissue of patients.

Author(s): Hong Li, Chunde Li, Xiaodong Yi, Hong Liu, Yu Wang
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