Biomedical Research

Objective: To investigate the effects of target-controlled infusion of propofol and remifentanil on intraoperative awareness of patients undergoing epilepsy surgery.

Methods: A total of 100 epileptic patients admitted in the neurosurgery department in our hospital to undergo minimally invasive surgery were selected from May 2015-2016. The patients were randomly and equally divided into the observation (propofol and remifentanil) group and control (conventional manual-controlled infusion) group. The heart rate (HR) and blood oxygen concentration (SpO2) of the patients were recorded before the operation, after anaesthesia administration for 3 min and 10 min, and post operation. Intraoperative awareness of patients was observed to assess the aesthetic effect. Pain degrees of patients were evaluated at 3, 6, 10 and 15 days post operation.

Results: Preoperative HR index in the observation group was 78.1 ± 9.5, with no statistically significant difference compared with the control group. The HRs in the observation group after anaesthesia administration for 3 min and 10 min were 76.4 ± 8.9 and 77.3 ± 6.8, respectively, compared with the control group, and no statistically significant difference was found (P<0.05). The preoperative SpO2 level in the observation group was 99.1 ± 0.2, and no significant difference compared with the control group was found. After administration for 3 min, the SpO2 level was (97.6 ± 2.8), which did not significantly differ compared with the control group (P<0.05). No significant difference in postoperative blood pressures was found between the two groups (P>0.05). By contrast, significant difference in intraoperative awareness was found between the two groups (P<0.05). The pain scores of patients in the observation group were significantly lower than those of the control group at 3, 6, 10, and 15 days post operation. Significant difference was found in the scores between the two groups (P<0.05).

Conclusion: Propofol and remifentanil target-controlled infusion anaesthesia resulted in more rapid induction and lower intraoperative awareness of patients undergoing epilepsy surgery. Moreover, the maintenance of anaesthesia was more stable, and the effect was better.

Author(s): Shi-Qiang Zhang, Li-Jun Xue, Qing-Yu Liu
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