Biomedical Research

Objective: To judge the female progesterone receptor proteins in the biological behavior of endometrial carcinoma tissue, for the diagnosis, treatment and prognosis of endometrial carcinoma.

Methods: In October 2012 to 2012 years in our hospital's collection of 79 example intrauterine membrane carcinoma specimens, 48 cases of normal endometrium and 51 cases of atypical hyperplasia of endometrium specimens were collected as specimens for analysis, using immunohistochemical method to three kinds of tested specimens of female progesterone receptor protein expression, analysis of the female progesterone receptor protein in normal endometrium, atypical hyperplasia of endometrium and endometrial carcinoma tissue expression differences of endometrial carcinoma tissues and research the female progesterone receptor protein expression and clinical pathological characteristics and treatment outcome of correlation.

Results: The G1 stage endometrial cancer patients with female progesterone receptor protein positive expression rate (21.16%) is significantly higher than grade G3, G3 endometrial cancer of the female progesterone receptor protein positive expression rate (34.78% and 30.77%), compared with significant difference (P<0.05); I period surgical pathology in patients with endometrial cancer of the female progesterone receptor protein positive expression rate (51.51%) was significantly higher than that of IIIV surgical pathology in patients with endometrial cancer of the female progesterone receptor protein positive expression rate (37.50%, 29.41% and 46.13%), compared with significant difference (P<0.05); Positive expression in patients with postoperative cumulative survival rate (86.67%) is significantly higher than the negative expression in patients with postoperative cumulative survival rate (71.05%), compared with significant difference (χ2=1.556, P<0.05).

Conclusion: Positive protein expression of estrogen and progesterone receptors may be served as the reference indicator for prognostic observation of treatment for patients with endometrial cancer.

Author(s): Cao Hongying, Wang An, Zhang Yongtao
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