Biomedical Research

Recently, plant-derived phytoestrogens have been shown to possess promising results for bone preservation and bone augmentation. Kaempferol, one of flavanols, is known to possess osteogenic effects and ability to stimulate bone formation. This study was designed to investigate the effect of Kaempferol on the process of bone healing in standardized mouse tibia fracture model. Oral administration of Kaempferol (0.2, 0.5 and 5 mg/kg body weight) to mice with fractured tibiae demonstrated an increase in callus formation and new bone formation as evidenced by the measurement of callus diameter and H&E staining, respectively at 21 days post-fracture. In addition, radiographic examination carried out at early stages of fracture healing process (11 days and 14 days post-fracture) revealed prior appearances of denser and bigger calluses in Kaempferol (0.5 mg/kg) treated group than that from control. Taken together, it can be concluded that Kaempferol potentiates fracture healing by increasing callus formation and initiating bone remodeling process.

Author(s): Lich Thi Nguyen, Otgonbayar Maidar, Ashish Ranjan Sharma, Garima Sharma, Heung Cheol Kim, Seonghun Park, Sang-Soo Lee, Ju-Suk Nam
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