Biomedical Research

The common reason behind the development of thyrotoxic heart disease is toxic diffuse goiter via hyperthyroidism. The effect of cardiovascular complexities and quality of life related to health in Chinese patients with thyrotoxic heart disease secondary to toxic diffuse goiter has been evaluated. During July 2013-June 2015 patients were diagnosed with thyrotoxic heart disease secondary to toxic diffuse goiter. Clinical assessment was performed at baseline and after restoration of euthyroid state follow-up. A questionnaire was created and used to study the quality of life related to health in them. Cohort study data for 73 patients was obtained. However, around half (35) of these patients with thyrotoxic heart disease secondary to toxic diffuse goiter were agreed to participate further in investigation of their quality of life related to health. The frequency of cardiovascular complexities before and after anti-thyroid therapy was recorded. A significant reduction in respective values was observed as: thyrotoxic cardiomyopathy (78% vs. 24%), ventricular extrasystole (72% vs. 7%), systolic blood pressure (158 vs. 126; in mm), diastolic blood pressure (85 vs. 68; in mm), congestive cardiac failure (68 vs. 18; in %), resting heart rate (124 vs. 76; in bpm) and atrial fibrillation (71 vs. 19; in %). In all the domains, improvement in quality of life related to health was observed. There is a strong association of reduction in cardiovascular complexities and of increment in quality of life related to health with respect to restoration of euthyroidism in Chinese patients.

Author(s): Dacheng Yang, Fengjun Liu, Teng Ma
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