Biomedical Research

Objectives: Essential hypertension is the most common chronic disease which is associated with an array of long-term end-organ diseases. Clinically, it would be helpful to detect high-risk patients early in development process of the disease, in order to avoid or delay the onset of comorbidities. The aim of our study was to evaluate the laboratory parameters which are possibly related to the onset of Ischemic Stroke (IS) in essential hypertension, and identify the strongest predicting laboratory parameters.

Methods: Totally 377 consecutive patients with a primary diagnosis of hypertension were recruited in our study. These patients were categorized according to the presence of IS. Nineteen routine laboratory parameters, such as Alkaline Phosphatase (ALP), Homocysteine (Hcy) and Fibrinogen (Fbg) were evaluated in all subjects.

Results: Hypertensive patients have higher serum UA, ACE and HP levels than control patients. More importantly, ALP, Hcy, Fbg, WBC and BUN levels were higher in the group with IS compared with other groups. Three out of 19 laboratory parameters were significantly related with IS in essential hypertension patients on backward elimination including: ALP (1.88; 95% CI: 1.38 to 2.61), Hcy (1.62; 95% CI: 1.17 to 2.25), and Fbg (1.85; 95% CI: 1.35 to 2.52).

Conclusions: According to our results, ALP, Hcy, and Fbg levels were significantly higher in patients with IS, we suggest that the three laboratory parameters were the strongest related to onset of IS in essential hypertension in our patient population.

Author(s): Yaru Liang, Peisong Chen, Yanhong Sun, Pinning Feng, Bin Huang, Tang Jiang
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