Biomedical Research

Objective: This study investigated the expression of chemotactic factor CCL5 in gastric cancer tissue and its correlation with macrophage marker CD86.

Methods: Fifty patients diagnosed with gastric cancer in our hospital from Jan 2015 to Dec 2016 were selected. Pathological tissue samples were tested.

Results: The expression levels of CCL5 and CD68 correlate with tumour size, degree of tumour invasion, lymphatic metastasis, pathological grading and tumour thrombus but are unrelated to patient age and gender. A significantly positive correlation exists between the expression of CCL5 and CD68 in gastric cancer tissues (r=0.814, P<0.05).

Conclusions: High expression levels of CCL5 and CD68 promote the growth and spread of gastric cancer tissues, lymphatic metastasis, and tumour differentiation. CCL5 and CD68 positively correlate with each other and could be used as new therapeutic targets for gastric cancer.

Author(s): Xinhai Han, Baoge Qu
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