Biomedical Research

Solubilizing drugs which are poorly water-soluble is a challenging factor and really vital issue in screening studies of new drug moieties as well as formulation development research. It leads to difficulties in several developmental, manufacturing and administrative processes. Furthermore, due to their poor pharmacokinetics the clinical trials of these drugs have witnessed a great failure. The aim of our research work is to promote mixed solvency concept by formulating the topical solution (lotion) and topical gel of poorly water-soluble drug piroxicam by decreasing the individual solubilizer concentration in small proportion for expected enhancement of drug solubility in water. For poorly water soluble drug piroxicam, solubilizers such as sodium benzoate, sodium citrate, sodium caprylate, arginine, valine, benzoic acid, poloxamer 407 and niacinamide has been used in combinations as mixed solvent systems. The procured sample of piroxicam was characterized by melting point, UV spectroscopy, IR and DSC studies. The formulations were evaluated for various properties of solution and gels such as pH, freeze thaw study and thin layer chromatography, physical appearance, etc. Mixed solvency concept was successfully utilized for formulation development of marketable product of piroxicam.

Author(s): Anirudha Padiyar, Maheshwari RK
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