Biomedical Research

Objective: This study aims to investigate the impact of Poria, Cinnamon Twig, Bighead Atractylodes and Licorice Decoction (PCBLD) with Pepperweed and Jujube Lung-Draining Decoction (PJLD) on Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP) and Angiotensin (Ang) II in Chronic Heart Failure (CHF) rats, to further shed light on the effective mechanism of classic Chinese herbal formulas for CHF.

Materials and Methods: Ninety Wistar rats were randomly allocated into modeling group (Group A) and blank control group (Group K). Animals in group A were prepared with Adriamycin (Adr) injection into their abdomen for CHF model. Six weeks after modeling, the CHF rats were randomly aligned to blank modeling group (Group M), Warming Yang and Desolving Phlegm group (Group W), Resolving Phlegm by decoction removing Guizhi group (Group Q). Rats in group W and Q were intragastrically administrated corresponding decoctions at 2 h after the final Adr injection, but not for group M or K. The herbal medicines were given once a day for 4 consecutive weeks. The levels of ANP, BNP and Ang II were tested after 4 weeks treatment.

Results: The level of ANP, BNP and Ang II in group M was significantly elevated, compared with group K (P<0.01), after treatment, the levels of BNP and Ang II in group W and Q were significantly reduced, respectively compared with group M (P<0.01). But after treatment, there was no significant change for the levels of ANP in group W or Q as compared with group M (P>0.05).

Conclusion: PCBLD with PJLD can improve the level of BNP and Ang II of CHF rats, which could be a potential mechanism of the classic formula treating CHF.

Author(s): Kai Li, Qi Zhang, JianHu Xu, Ziqing Yang, Xiaotong Ren, Leibing Li, Chiqiong Luo, Ye Xiao, Lu Xu, Linxian Li
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