Biomedical Research

Objective: To study the influence of blood glucose level on incidence of pulmonary infection and prognosis in patients with diabetes mellitus complicated with severe cerebral infarction, so as to provide valuable reference for clinical research.

Methods: 120 cases of diabetes mellitus complicated with severe cerebral infarction in our hospital from April 2011 to November 2016 were enrolled as the research objects and were randomized to observation group and control group, with 60 cases in each group. 2 h postprandial blood glucose was detected in all patients, blood glucose remained at 4.4 to 8.0 mmol/L in observation group and at 8.0 to 11.1 mmol/L in control group. Pulmonary infection and mortality were compared between the two groups, and the influence of blood glucose on the National Institutes of Health Stroke Scale (NIHSS), acute physiology and chronic health evaluation II (APACHE II), Glasgow Coma Scale (GCS) scores and mortality rate were analysed.

Results: The incidence of pulmonary infection and mortality of observation group were significantly lower than those of control group (P<0.05). Before treatment, there were no significant difference between the two groups on NIHSS, APACHE II, GCS scores (P>0.05). After 7 d of treatment, NIHSS, APACHE scores of patients in observation group were significantly lower than those of control group, while GCS score was significantly higher than control group (P<0.05). Univariate analysis showed that age, duration of diabetes and blood glucose level were correlated with survival prognosis, and the difference was statistically significant (P<0.05).

Conclusion: Strict control of blood glucose level in patients with diabetes mellitus complicated with severe cerebral infarction can better reduce the incidence and mortality of pulmonary infection, so as to achieve the purpose of improving the prognosis of patients.

Author(s): Song Jianwei, Yan Hanwen, Sheng Jie, Cai Jundan, Zhang Xiaojun, Wu Yun
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