Biomedical Research

Objective: This study investigated the influence of sevoflurane anesthesia on postoperative recovery of cognitive disorder in elderly patients treated with non-cardiac surgery.

Methods: A total of 112 elderly patients treated with non-cardiac surgery from January 2015 to January 2016 were chosen, and then divided into the observation group (n=56) and the control group (n=56) randomly. The control group was treated with propofol and remifentanil anesthesia, whereas the observation group was treated with sevoflurane anesthesia. The postoperative cognitive functions of the two groups were compared.

Results: The two groups have no statistically significant differences in terms of heart rate and blood pressure before anesthesia, before the surgery, 30 min in the surgery, and after the surgery (P>0.05). The Mini-Mental State Examination (MMSE) score (26.44 ± 0.76) 24 h after the surgery of the observation group is significantly lower than that of the control group (27.18 ± 0.72), showing statistically significant difference (P<0.05). However, no statistically significant differences of the MMSE scores before anesthesia and 6, 24, and 72 h after the surgery between the two groups have been observed (P>0.05). The observation group has lower incidence of cognitive disorder at 6 (3.57%) and 12 h (3.57%) after the surgery than the control group (P<0.05). Nevertheless, the two groups have no statistically significant difference in the incidence of cognitive disorder at 24 and 72 h after the surgery (P<0.05).

Conclusion: Sevoflurane anesthesia can shorten anesthesia time for elderly patients in non-cardiac surgery and reduce postoperative dysfunction in patients.

Author(s): Qi Liu, Chun-Liang Liu, Xiao-Ying Yang, Jun-Wei Ji, Sheng Peng
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