Biomedical Research

Background: To analyze the expression of Metadherin (MTDH), Carcinoembryonic Antigen related Cell adhesion Molecule 1 (CEACAM1) and Hepatitis B virus X protein (HBx) in HBV-associated Hepatocellular Carcinoma (HCC) tissues and clinical significance.

Methods: Total of 65 specimens of HBV-associated HCC tissues (the observation group) and 65 specimens of para-carcinoma tissues (the control group), which derived from 65 HBV-associated HCC patients in the pathologic department of our hospital from Jan 2015 to Dec 2016. The differences of expression levels of MTDH, CEACAM1 and HBx in tissues and its associations with the clinical pathological characteristics of HBV-associated HCC were analysed.

Results: The positive expression rates of MTDH and HBx in HBV-associated HCC tissues were significantly higher than those in the para-carcinoma tissues (60.00% vs. 32.31%, P<0.05; 43.08% vs. 64.62%, P<0.05). The positive expression rates of CEACAM1 in the HBV-associated HCC tissues was significantly lower than those in the para-carcinoma tissues (43.08% vs. 64.62%, P<0.05). The expressions of MTDH, CEACAM1 and HBx in the HBV-associated HCC tissues were significantly correlated with the TNM stage, portal vein invasion, lymph node metastasis and tissue differentiation (P<0.05). CEACAM1 and HBx were closely associated with the tumor diameter and size (P<0.05).

Conclusion: The high expression of MTDH and HBx, the low expression of CEACAM1 was closely associated with TNM stage, portal vein invasion, lymph node metastasis and tissue differentiation degree in HBV-associated HCC tissues, MTDH and HBx might promote the development and occurrence of HBV-associated HCC by inhibiting the expression of CEACAM1.

Author(s): Gu-Ya Xie, Hong-Liang Ou, Ji Wang1, Gang Wang, Ya-Fen Wang
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