Biomedical Research

The aim of this study was to assess lipids, lipoprotein (a) profile and HbA1c in Qatari’s type 2 diabetes mellitus (DM) and to correlate the values with various risk factors. This case control study was conducted in Hamad General Hospital, Doha, State of Qatar from May 2004 to November 2005 in 214 cases (with diabetes) and 214 controls (without diabetes) aged 25 to 65 years, males and females and Qatari nationals. Face to face interviews were based on a questionnaire that included variables such as age, sex, family history, physical examination, fasting blood glucose, lipids, Lp (a) HbA1c cholesterol total, HDL, LDL and triglycerides analysis. The age, male gender, BMI , obesity, WHR were higher in diabetics, (p<0.001). The prevalence of hypertension was associated with the presence of diabetes (29% for diabetics vs. 4% for control group , p<0.001). The percentages of patients with Lp (a) above 300 mg/l were significantly different between the two groups (48% vs 23%, p<0.001). Diabetic patients had significantly higher TC (p<0.001); TG (p<0.001), LDL (p<0.001) and Lp (a) (p = 0.0045). In diabetic patients, Lp (a) correlates with total cholesterol (r=0.296; p<0.05), LDL-C (r=0.285; p<0.05), but marginally significant with ApoB (r=0.573, p<0.001), TG (r=0.288; p<0.05), and LDL-C (r=0.584; p<0.001). Similarly, ApoA1 significantly correlated with TC (r= 0.292; p<0.05), LDL-C (r= 0.305; p<0.001) and HDL-C (r=0.565; p<0.001. The present study revealed that obesity, consanguinity, total cholesterol, reduced HDL cholesterol and triglyceride were more prevalent in diabetic patients. Furthermore, this study has reported that diabetes state does not increase plasma Lp (a) concentrations and fail to show any association of Lp (a) levels with glycemic control in type 2 diabetic patients.

Author(s): Abdulbari Bener, Mahmoud Zirie, Mohammed H. Daghash, Abdulla O.A.A. Al-Hamaq, Ghazi Daradkeh, Ammar Rikabi
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